Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects.
Belen BeginesTamara Ortiz-CerdaMaría Pérez-ArandaGuillermo MartínezManuel MerineroFederico Argüelles-AriasAna AlcudiaPublished in: Nanomaterials (Basel, Switzerland) (2020)
The complexity of some diseases-as well as the inherent toxicity of certain drugs-has led to an increasing interest in the development and optimization of drug-delivery systems. Polymeric nanoparticles stand out as a key tool to improve drug bioavailability or specific delivery at the site of action. The versatility of polymers makes them potentially ideal for fulfilling the requirements of each particular drug-delivery system. In this review, a summary of the state-of-the-art panorama of polymeric nanoparticles as drug-delivery systems has been conducted, focusing mainly on those applications in which the corresponding disease involves an important morbidity, a considerable reduction in the life quality of patients-or even a high mortality. A revision of the use of polymeric nanoparticles for ocular drug delivery, for cancer diagnosis and treatment, as well as nutraceutical delivery, was carried out, and a short discussion about future prospects of these systems is included.
Keyphrases
- drug delivery
- current status
- cancer therapy
- drug release
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- peritoneal dialysis
- total knee arthroplasty
- squamous cell carcinoma
- prognostic factors
- oxidative stress
- type diabetes
- risk factors
- coronary artery disease
- cardiovascular events
- cardiovascular disease
- emergency department
- adverse drug
- young adults
- drug induced
- electronic health record