A Recurrent ADPRHL1 Germline Mutation Activates PARP1 and Confers Prostate Cancer Risk in African American Families.

Guanyi ZhangZemin WangJasmin BavarvaKatherine J KuhnsJianhui GuoElisa M LedetChiping QianYuan LinZhide FangJovanny Zabaleta Luis Del Valle Jennifer J HuDiptasri MandalWanguo Liu

Published in: Molecular cancer research : MCR (2022)

This study highlights a potential strategy for ADPRHL1 mutation detection in prostate cancer-risk assessment and a potential therapeutic application for individuals with prostate cancer in AA families.

Keyphrases

prostate cancer
african american
radical prostatectomy
risk assessment
dna repair
human health
dna damage
loop mediated isothermal amplification
climate change
label free
benign prostatic hyperplasia
real time pcr