A small protein coded within the mitochondrial canonical gene nd4 regulates mitochondrial bioenergetics.
Laura KienzleStefano BettinazziThierry ChoquetteMarie A BrunetHajar Hosseini KhoramiJean-François JacquesMathilde MoreauXavier RoucouChristian R LandryAnnie AngersSophie BretonPublished in: BMC biology (2023)
Many human mitochondrial translated ORFs might have so far gone unnoticed. By ignoring mtaltORFs, we have underestimated the coding potential of the mitogenome. Alternative mitochondrial peptides such as MTALTND4 may offer a new framework for the investigation of mitochondrial functions and diseases.