Transition Metal-Free Domino Hydroamination/Isomerization/Transamidation Sequence: An Entry to Trifluorinated γ-Lactams.
Dorian SchutzClément GommengingerBaptiste MoegleMaxime HourtouleLudovik Noël-DuchesneauLaurence MieschPublished in: The Journal of organic chemistry (2024)
A method for the construction of trifluorinated-5-methylenepyrrolidinone is reported. This strategy combines an acid-catalyzed two-carbon homologation process between ynamides and aldehydes, providing CF 3 -substituted dienes followed by a metal-free domino hydroamination/isomerization/transamidation sequence, delivering trifluorinated-5-methylenepyrrolidinone stereoselectively.