Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice.
Irene Santos-GarcíaCarmen Rodríguez-CuetoPatricia VillegasFabiana PiscitelliAnna LauritanoChe-Kun J ShenVincenzo Di MarzoJavier Fernández-RuizEva de LagoPublished in: Journal of neuroinflammation (2023)
Our data confirmed the potential of elevating the endocannabinoid tone as a therapy against TDP-43-induced neuropathology in FTD, limiting glial reactivity, preserving neuronal integrity and improving cognitive, emotional and social deficits.
Keyphrases
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