Prevalence of progressive multifocal leukoencephalopathy (PML) in adults and children with systemic lupus erythematosus.

Teja KapoorPooja MahadeshwarJoyce Hui-YuenKayla QuinniesNicholas TatonettiYevgeniya GartshteynCathy GuoLaura Geraldino-PardillaAnca D Askanase

Published in: Lupus science & medicine (2021)

Among 7455 adult patients with SLE ICD codes, there were two PML cases, with only one confirmed case associated with severe lymphopenia and immunosuppressants, corresponding to a prevalence of 13-27 per 100 000 patients. No PML cases in pSLE were found. A high index of suspicion in patients with SLE and CNS manifestations is required for the prompt diagnosis of PML.

Keyphrases

systemic lupus erythematosus
disease activity
end stage renal disease
risk factors
ejection fraction
newly diagnosed
multiple sclerosis
chronic kidney disease
prognostic factors
peritoneal dialysis
blood brain barrier
rheumatoid arthritis
patient reported outcomes
drug induced