The measurement of KRAS G12 mutants using multiplexed selected reaction monitoring and ion mobility mass spectrometry.

Rachel L NormanRajinder SinghJames I LangridgeLeong L NgDonald J L Jones

Published in: Rapid communications in mass spectrometry : RCM (2020)

This study advocates that LC/SRM and IMS/MS could both be used to identify single amino acid substitutions in KRAS as an alternative to commonly used methods such as circulating tumour DNA analysis.

Keyphrases

mass spectrometry
wild type
liquid chromatography
amino acid
multiple sclerosis
gas chromatography
capillary electrophoresis
ms ms
high resolution
circulating tumor
single molecule
single cell
nucleic acid