Elucidation of the Key Therapeutic Targets and Potential Mechanisms of Marmesine against Knee Osteoarthritis via Network Pharmacological Analysis and Molecular Docking.

Hanbing SongHongpeng LiuXiaodong LiBing LvZonghan TangQipeng ChenDan-Qi Zhang Fei Wang

Published in: Computational and mathematical methods in medicine (2022)

Marmesine exerts the therapeutic effects against OA through multitarget and multipathways, in which EGFR, CASP3, MMP9, PPARG, and MAPK1 might be hub genes. Our research indicated that the combination of bioinformatics and network pharmacology could serve as an effective approach for investigating the potential mechanisms of natural product.

Keyphrases

knee osteoarthritis
molecular docking
small cell lung cancer
molecular dynamics simulations
network analysis
human health
signaling pathway
epidermal growth factor receptor
bioinformatics analysis
oxidative stress
tyrosine kinase
risk assessment
climate change
cell migration
data analysis