A Novel Smad7 Genetic Variant Mapping on the Genomic Region Targeted by Mongersen Is Associated with Crohn's Disease.
Davide Di FuscoIrene MarafiniCarmine StolfiEdoardo TronconeSara OnaliElisabetta LolliFlavio CaprioliStefano MazzaCascella RaffaellaLaura ManzoPaola BorgianiPaolo GiuffridaAntonio Di SabatinoIvan MonteleoneGiovanni MonteleonePublished in: Biomedicines (2020)
This is the first study to show an association between Smad7 rs144204026 SNP and CD patients. Data indicate that such a variant does not negatively influence the in vitro inhibitory effect of Smad7 AS on Smad7.
Keyphrases
- transforming growth factor
- epithelial mesenchymal transition
- end stage renal disease
- genome wide
- ejection fraction
- chronic kidney disease
- copy number
- peritoneal dialysis
- high resolution
- prognostic factors
- high density
- patient reported outcomes
- machine learning
- drug delivery
- mass spectrometry
- artificial intelligence