VU0810464, a non-urea G protein-gated inwardly rectifying K+ (Kir 3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir 3 channels and reduces stress-induced hyperthermia in mice.

Baovi N VoKristopher K AbneyAllison AndersonEzequiel Marron Fernandez de VelascoMichael A BenneyworthJohn Scott DanielsRyan D MorrisonCorey R HopkinsCharles David WeaverKevin Wickman

Published in: British journal of pharmacology (2019)

VU0810464 represents a new class of Kir 3 channel activator with enhanced selectivity for Kir 3.1/3.2 channels. VU0810464 may be useful for examining Kir 3.1/3.2 channel contributions to complex behaviours and for probing the potential of Kir 3 channel-dependent manipulations to treat neurological disorders.

Keyphrases

stress induced
type diabetes
risk assessment
immune response
human health
subarachnoid hemorrhage