Layer-specific impairment in the developing lateral entorhinal cortex of immune-challenged Disc1 +/- mice.

mice. Abstract figure legend Layer-specific deficits in the lateral entorhinal cortex of immune -challenged Disc1+/- mice. Layer-specific deficits in the lateral entorhinal cortex of immune-challenged Disc1+/- mice emerge early during development and particularly impair neurons in layers 2b and 3, which project to the hippocampus. These changes might underly reduced entorhinal drive of the hippocampal-prefrontal network and early network dysfunction associated with cognitive deficits in mental disorders. This article is protected by copyright. All rights reserved.