Transcriptome and methylome analysis of CNS germ cell tumor finds its cell-of-origin in embryogenesis and reveals shared similarities with testicular counterparts.
Hirokazu TakamiAsmaa ElzawahryYasin MamatjanShintaro FukushimaKohei FukuokaTomonari SuzukiTakaaki YanagisawaYuko MatsushitaTaishi NakamuraKaishi SatomiShota TanakaAkitake MukasaNobuhito SaitoMasayuki KanamoriToshihiro KumabeTeiji TominagaKeiichi KobayashiMotoo NaganeToshihiko IuchiKaoru TamuraTaketoshi MaeharaKazuhiko SugiyamaKoji YoshimotoKeiichi SakaiMasahiro NonakaAkio AsaiKiyotaka YokogamiHideo TakeshimaYoshitaka NaritaSoichiro ShibuiYoichi NakazatoNatsuko HamaYasushi TotokiMamoru KatoTatsuhiro ShibataRyo NishikawaMasao MatsutaniKoichi IchimuraPublished in: Neuro-oncology (2022)
These results suggested that the pathophysiology of GCTs was less dependent on their site of origin and more dependent on the state of differentiation as well as on the tumor microenvironment balance. This study revealed distinct biological properties of GCTs, which will hopefully lead to future treatment development.