Login / Signup

Gain-of-function mutations in Trim71 linked to congenital hydrocephalus.

Yingying ChenXianfa YangNaihe Jing
Published in: PLoS biology (2023)
The genetic basis of congenital hydrocephalus is only partially understood. A new study in PLOS Biology reports a potential gain-of-function pathological mechanism of congenital hydrocephalus in mouse embryonic stem cells that involves Wnt-β-catenin signaling pathway regulation.
Keyphrases
  • subarachnoid hemorrhage
  • embryonic stem cells
  • cerebrospinal fluid
  • stem cells
  • cell proliferation
  • genome wide
  • emergency department
  • gene expression
  • dna methylation
  • climate change