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Protein disulfide isomerase family member 4 promotes triple-negative breast cancer tumorigenesis and radiotherapy resistance through JNK pathway.

Jinqiu TaoCailin XueMeng CaoJiahui YeYulu SunHao ChenYinan GuanWenjie ZhangWeijie ZhangYongzhong Yao
Published in: Breast cancer research : BCR (2024)
The results of this study indicate that PDIA4 is an oncoprotein that promotes TNBC progression, and targeted therapy may represent a new and effective anti-tumor strategy, especially for patients with radiotherapy resistance.
Keyphrases
  • early stage
  • locally advanced
  • radiation therapy
  • radiation induced
  • signaling pathway
  • cell death
  • squamous cell carcinoma
  • amino acid
  • oxidative stress
  • rectal cancer
  • induced apoptosis