Biocompatible Vibration-Actuated Omni-Droplets Rectifier with Large Volume Range Fabricated by Femtosecond Laser.

High-performance droplet transport is crucial for diverse applications such as biomedical detection, chemical micro-reaction, and droplet microfluidics. Despite extensive progresses, traditional passive strategies and active strategies are restricted to limited liquid types, small droplet volume ranges, and poor biocompatibilities. Moreover, more challenges occur for the biological fluids due to the large viscosity and low surface tension. Here we report a vibration-actuated omni-droplets rectifier (VAODR) consisting of slippery ratchets arrays fabricated by femtosecond laser and vibration platforms. Through the relative competition between the asymmetric adhesive resistance originating from the lubricant meniscus on VAODR and the periodic inertial driving force originating from isotropic vibration, the fast (up to ∼60 mm/s), programmable and robust transport of droplets are achieved for a large volume range (0.05-2,000 μL, Vmax /Vmin ∼40,000) and in various transport modes including liquid slugs transport in the VAODR-based tube, programmable and sequential transport, and "cable-car"-like bidirectional transport. Our VAODR is also general to a high diversity of biological and medical fluids, and thus can be used for the biomedical detection such as ABO blood group test and anti-cancer drugs screening. Our strategies provide a complementary and promising platform for maneuvering omni-droplets that are fundamental to biomedical applications as well as other high-throughput omni-droplet operation fields. This article is protected by copyright. All rights reserved.