Human umbilical cord-derived mesenchymal stromal cells ameliorate aging-associated skeletal muscle atrophy and dysfunction by modulating apoptosis and mitochondrial damage in SAMP10 mice.
Limei PiaoZhe HuangAiko InoueMasafumi KuzuyaXian Wu ChengPublished in: Stem cell research & therapy (2022)
Our results suggest that UC-MSCs can improve sarcopenia-related skeletal muscle atrophy and dysfunction via anti-apoptosis, anti-inflammatory, and mitochondrial biogenesis mechanisms that might be mediated by an AMPK-PGC1-α axis, indicating that UC-MSCs may provide a promising treatment for sarcopenia/muscle diseases.
Keyphrases
- skeletal muscle
- oxidative stress
- umbilical cord
- mesenchymal stem cells
- bone marrow
- insulin resistance
- anti inflammatory
- endothelial cells
- high fat diet induced
- endoplasmic reticulum stress
- signaling pathway
- type diabetes
- combination therapy
- metabolic syndrome
- cell proliferation
- replacement therapy
- protein kinase
- smoking cessation
- drug induced