Progress and pitfalls in the use of immunotherapy for patients with triple negative breast cancer.
Elisa AgostinettoAgnese LosurdoGuilherme Nader MartaArmando SantoroKevin PunieRomualdo BarrosoLazar PopovicCinzia SolinasMarleen KokEvandro de AzambujaMatteo LambertiniPublished in: Expert opinion on investigational drugs (2022)
Triple-negative breast cancer (TNBC); breast cancers (BCs); estrogen receptor (ER); progesterone receptor (PgR); human epidermal growth factor-2 (HER-2); basal-like 1 (BL1), basal-like 2 (BL2); mesenchymal (MES); mesenchymal stem-like (MSL); immunomodulatory (IM); luminal androgen receptor (LAR); basal-like immunosuppressed (BLIS); basal-like immune-activated (BLIA); tumor-infiltrating lymphocytes (TILs); tumor mutational burden (TMB); immune cells (ICs); immunohistochemistry (IHC); overall response rate (ORR); overall survival (OS); progression-free survival (PFS); intention-to-treat (ITT); hazard ratio (HR); confidence interval (CI); Food and Drug Administration (FDA); European Medicines Agency (EMA); immune checkpoint inhibitors (ICI); Combined Positive Score (CPS); disease control rate (DCR); neoadjuvant chemotherapy (NACT); pathological complete response (pCR); event-free survival (EFS); disease-free survival (DFS); residual cancer burden (RCB); San Antonio Breast Cancer Symposium (SABCS); antibody-drug conjugates (ADCs); PARP inhibitors (PARPi); clinical benefit rate (CBR); Histone deacetylase inhibitors (HDACi); Dendritic cell (DC); talimogene laherparepvec (TVEC); granulocyte-macrophage colony-stimulating factor (GM-CSF); mismatch repair deficiency (dMMR).
Keyphrases
- free survival
- estrogen receptor
- neoadjuvant chemotherapy
- growth factor
- dendritic cells
- drug administration
- histone deacetylase
- stem cells
- bone marrow
- endothelial cells
- locally advanced
- lymph node
- peripheral blood
- sentinel lymph node
- dna damage
- risk factors
- adipose tissue
- immune response
- squamous cell carcinoma
- early stage
- rectal cancer
- endoplasmic reticulum
- wound healing