Stereotactic Body Radiation Therapy (SBRT) for Oligorecurrent/Oligoprogressive Mediastinal and Hilar Lymph Node Metastasis: A Systematic Review.
Salvatore CozziEmanuele AlìLilia BardosciaMasoumeh NajafiAndrea BottiGladys BlandinoLucia GiaccheriniMaria Paola RuggieriMatteo AugugliaroFederico IoriAngela SardaroCinzia IottiPatrizia CiammellaPublished in: Cancers (2022)
From the present review, it is not possible to draw definitive conclusions because of the heterogeneity of the studies analyzed. However, SBRT appears to be a safe and effective option in the treatment of mediastinal and hilar lymph node recurrence, with a good toxicity profile. Its use in clinical practice is still limited, and there is extensive heterogeneity in patient selection and fractionation schedules. Good performance status, small PTV volume, absence of previous thoracic irradiation, and administration of a high biologically effective dose (BED) seem to be factors that correlate with greater local control and better survival rates. In the presence of symptoms related to the thoracic lymph nodes, SBRT determines a rapid control that lasts over time. We look forward to the prospective studies that are underway for definitive conclusions.
Keyphrases
- lymph node
- radiation therapy
- lymph node metastasis
- locally advanced
- radiation induced
- clinical practice
- neoadjuvant chemotherapy
- spinal cord
- sentinel lymph node
- single cell
- squamous cell carcinoma
- case control
- papillary thyroid
- free survival
- case report
- oxidative stress
- combination therapy
- physical activity
- rectal cancer
- replacement therapy