Pseudomonas aeruginosa colonization enhances ventilator-associated pneumonia-induced lung injury.
Tzyy-Bin TsayYu-Zhen JiangChing-Mei HsuLee-Wei ChenPublished in: Respiratory research (2016)
PA colonization plays an important role in PA VAP-induced lung injury through the induction of JNK1-mediated inflammation. PA-induced VAP causes lung injury through JNK signaling pathway in the lungs. JNK inhibition in ICU patients with higher percentages of PA colonization may reduce VAP-induced lung injury and mortality.
Keyphrases
- signaling pathway
- high glucose
- diabetic rats
- pseudomonas aeruginosa
- cell death
- oxidative stress
- drug induced
- induced apoptosis
- cystic fibrosis
- type diabetes
- intensive care unit
- cell proliferation
- pi k akt
- epithelial mesenchymal transition
- coronary artery disease
- escherichia coli
- acute respiratory distress syndrome
- cardiovascular events
- mechanical ventilation
- candida albicans
- biofilm formation