Interaction potential of the dual orexin receptor antagonist ACT-541468 with CYP3A4 and food: results from two interaction studies.

Marie-Laure BoofAbir AlatrachMike UferJasper Dingemanse

Published in: European journal of clinical pharmacology (2018)

Overall, ACT-541468 has been determined as CYP3A4 substrate but without any perpetrator drug-drug interaction potential regarding CYP3A4 in humans. Food affected ACT-541468 absorption without modifying overall exposure.

Keyphrases

human health
risk assessment
climate change
structural basis