Quantitative sensory testing and skin biopsy findings in late-onset ATTRv pre-symptomatic carriers: relationships with predicted time of disease onset (PADO).

Our findings confirm that IENFD reduction and QST abnormalities may occur early in ATTRv pre-symptomatic carriers, often with a non-length dependent pattern. However, only sural SAP amplitude and QST parameters correlated with delta-PADO, suggesting that serial combined QST and NCS evaluation could be useful in ATTRv pre-symptomatic carriers' follow-up. This article is protected by copyright. All rights reserved.