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MRI Liver Imaging Integrated with Texture Analysis in Native Liver Survivor Patients with Biliary Atresia after Kasai Portoenterostomy: Correlation with Medical Outcome after Surgical Treatment.

Andrea Delli PizziArnaldo StanzioneCarlo RicciardiFabiola Di DatoNoemi PisaniGregorio Delli PaoliMarco De GiorgiRaffaele LiuzziCarmine MollicaValeria RomeoRaffaele IorioMario CesarelliArturo BrunettiSimone Maurea
Published in: Bioengineering (Basel, Switzerland) (2023)
Kasai portoenterostomy (KP) plays a crucial role in the treatment of biliary atresia (BA). The aim is to correlate MRI quantitative findings of native liver survivor BA patients after KP with a medical outcome. Thirty patients were classified as having ideal medical outcomes (Group 1; n = 11) if laboratory parameter values were in the normal range and there was no evidence of chronic liver disease complications; otherwise, they were classified as having nonideal medical outcomes (Group 2; n = 19). Liver and spleen volumes, portal vein diameter, liver mean, and maximum and minimum ADC values were measured; similarly, ADC and T2-weighted textural parameters were obtained using ROI analysis. The liver volume was significantly ( p = 0.007) lower in Group 2 than in Group 1 (954.88 ± 218.31 cm 3 vs. 1140.94 ± 134.62 cm 3 ); conversely, the spleen volume was significantly ( p < 0.001) higher (555.49 ± 263.92 cm 3 vs. 231.83 ± 70.97 cm 3 ). No differences were found in the portal vein diameter, liver ADC values, or ADC and T2-weighted textural parameters. In conclusion, significant quantitative morpho-volumetric liver and spleen abnormalities occurred in BA patients with nonideal medical outcomes after KP, but no significant microstructural liver abnormalities detectable by ADC values and ADC and T2-weighted textural parameters were found between the groups.
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