Mitigating the prevalence and function of myeloid-derived suppressor cells by redirecting myeloid differentiation using a novel immune modulator.

Liliana OliverRydell AlvarezRaquel DiazAnet ValdésSean H ColliganMichael J NemethDanielle Y F TwumAudry FernándezOlivia Fernández-MedinaLouise M CarlsonHan YuKevin H EngMary L HensenMaura L Rábade-ChediakLuis Enrique FernándezKelvin P LeeLeslie PerezJason B Muhitch Circe Mesa Scott I Abrams

Published in: Journal for immunotherapy of cancer (2022)

Altogether, these data revealed VSSP as a novel regulator of myeloid biology that mitigates MDSCs in cancer patients and reinstates a more normal myeloid phenotype that potentially favors immune activation over immune suppression.

Keyphrases

dendritic cells
bone marrow
acute myeloid leukemia
induced apoptosis
risk factors
cell cycle arrest
electronic health record
single cell
transcription factor
big data
oxidative stress
signaling pathway
machine learning
cell proliferation