Epimorphic regeneration of the mouse digit tip is finite.
Connor P DolanTae-Jung YangKatherine ZimmelFelisha ImholtOsama QureshiAlyssa FalckJoshua GregoryMacie MayesKayla RitchieHannah KoesterBenjamin DanielMingquan YanLing YuLarry J SuvaDana GaddyLindsay A DawsonKen MuneokaRegina BrunauerPublished in: Stem cell research & therapy (2022)
In sum, these data suggest that epimorphic regeneration in mammals is finite and due to the exhaustion of the proliferation and differentiation capacity of the blastema cell source.