Insulin resistance and hyperandrogenism drive steatosis and fibrosis risk in young females with PCOS.

Salvatore PettaAlessandro CiresiJessica BiancoVincenzo GeraciRoberta BoemiLuigi GalvanoFranco MagliozzoGiovanni MerlinoAntonio CraxìCarla Giordano

Published in: PloS one (2017)

We found that PCOS is an independent risk factor for steatosis, and that, IR and hyperandrogenism, this last especially in nonobese patients, are the key players of liver damage in PCOS.

Keyphrases

polycystic ovary syndrome
insulin resistance
high fat diet
adipose tissue
metabolic syndrome
skeletal muscle
high fat diet induced
end stage renal disease
type diabetes
ejection fraction
chronic kidney disease
oxidative stress
peritoneal dialysis
prognostic factors
glycemic control
middle aged
weight loss