Drugs That Modify Cholesterol Metabolism Alter the p38/JNK-Mediated Targeted and Nontargeted Response to Alpha and Auger Radioimmunotherapy.

Riad LadjohounlouCatherine LozzaAlexandre PichardJulie ConstanzoJihad KaramPierre Le FurEmmanuel DeshayesVincent BoudousqSalomé PaillasMuriel BussonMarion Le BlayMarta JarlierSara MarcatiliManuel BardièsFrank BruchertseiferAlfred MorgensternJulien TorgueIsabelle Navarro-TeulonJean-Pierre Pouget

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Cell membrane-mediated nontargeted effects play a significant role during Auger and alpha RIT, and drugs that modulate cholesterol level, such as statins, could interfere with RIT efficacy.

Keyphrases

low density lipoprotein
cardiovascular disease
signaling pathway
high resolution mass spectrometry
cell death
cancer therapy
type diabetes
drug induced
drug delivery
liquid chromatography