Does the BNT162b2 Vaccine Trigger Antimelanoma Differentiation-Associated Gene 5 Antibody-Positive Interstitial Lung Disease?
Tomoyuki MutohMikihiro TakahashiTaichi NagaiMasataka KudoPublished in: The Journal of rheumatology (2022)
We read the report by Kitajima et al 1 with great interest. They demonstrated 4 cases of antimelanoma differentiation-associated gene 5 (anti-MDA5)-positive interstitial lung disease (ILD) manifested following SARS-CoV-2 vaccination and suggested the possibility of the increased incidence of anti-MDA5- associated ILD (anti-MDA5-ILD) due to the vaccination. This study interested us since we also encountered a case of new-onset anti-MDA5 antibody-positive clinically amyopathic dermatomyositis (CADM) with ILD, developed 8 weeks after BNT162b2 vaccination during the SARS-CoV-2 vaccination campaign in Japan.
Keyphrases
- interstitial lung disease
- systemic sclerosis
- sars cov
- rheumatoid arthritis
- idiopathic pulmonary fibrosis
- breast cancer cells
- genome wide
- copy number
- cell cycle arrest
- respiratory syndrome coronavirus
- risk factors
- signaling pathway
- gene expression
- cell proliferation
- genome wide identification
- cell death
- disease activity
- gestational age
- pi k akt