Clinical, radiological and laboratory characteristics of central nervous system histoplasmosis: A systematic review of a severe disease.
Vítor Falcão de OliveiraWdson Luis Lima KruschewskyWilliam Kazunori SekiguchiSilvia F CostaAnna S LevinMarcello Mihailenko Chaves MagriGuilherme Diogo SilvaPublished in: Mycoses (2023)
Central nervous system histoplasmosis usually presents subacute-to-chronic symptoms in young adults. Neuroimaging patterns included not only focal lesions but also hydrocephalus, meningitis and vasculitis. Positive results were commonly found in CSF antigen and serology. Mortality was high, and treatment with liposomal amphotericin B followed by itraconazole may decrease mortality.