Acute Tubulointerstitial Nephritis in a Patient on Anti-Programmed Death-Ligand 1 Triggered by COVID-19: A Case Report.
Dimitry BuyanskyCatherine FallahaFrançois GougeonMarie-Noëlle PépinJean-François CailhierWilliam Beaubien-SoulignyPublished in: Canadian journal of kidney health and disease (2021)
We hypothesize that the viral infection along with checkpoint inhibitor use has created a proinflammatory environment which led to a loss of self-tolerance to renal parenchyma. Viruses may play a more important role in the pathogenesis of autoimmunity in this patient population than was previously thought.