Alterations of small non-coding RNA in the spermatozoa of mice with paternal experimental autoimmune epididymo-orchitis are associated with metabolic dysfunction in offspring.

Chen YangJianlin LiJin-Chuan LiuQunxiong ZengWilliam Shu-Biu YeungPhilip Chi-Ngong ChiuYong-Gang Duan

Published in: Andrology (2023)

We revealed that autoimmune epididymo-orchitis alters sncRNA profiles in mouse spermatozoa. Offspring from mice with autoimmune orchitis develop metabolic disorders. A comprehensive analysis of human and mouse inflammation data revealed an association between alterations in the miRNA and tsRNA profiles of epididymal spermatozoa and offspring phenotypes.

Keyphrases

high fat diet
multiple sclerosis
oxidative stress
high fat diet induced
endothelial cells
single cell
drug induced
big data
induced pluripotent stem cells
machine learning
data analysis
nucleic acid