SIRT1 Regulates N6 -Methyladenosine RNA Modification in Hepatocarcinogenesis by Inducing RANBP2-Dependent FTO SUMOylation.
Xiaoming LiuJianye LiuWen XiaoQinghai ZengHao BoYuxing ZhuLian GongDong HeXiaowei XingRuhong LiMing ZhouWei XiongYanhong ZhouJianda ZhouXiaohui LiFei GuoCanxia XuXiong ChenXiaoyan WangFen WangQiang WangKe CaoPublished in: Hepatology (Baltimore, Md.) (2020)
We demonstrate an important mechanism whereby SIRT1 destabilizes FTO, steering the m6 A+ of downstream molecules and subsequent mRNA expression in HCC tumorigenesis. Our findings uncover a target of SIRT1 for therapeutic agents to treat HCC.