Late Health Outcomes Among Survivors of Wilms Tumor Diagnosed Over Three Decades: A Report From the Childhood Cancer Survivor Study.
Brent R WeilAndrew Jackson MurphyQi LiuRebecca M HowellSusan A SmithChristopher B WeldonElizabeth A MullenArin L MadenciWendy M LeisenringJoseph P NegliaLucie M TurcotteKevin C OeffingerAmanda M TermuhlenSogol Mostoufi-MoabJennifer M LevineKevin R KrullYutaka YasuiLeslie L RobisonGregory T ArmstrongEric J ChowSaro H ArmenianPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
With approximately 40% of patients with newly diagnosed WT currently treated with VA alone, the burden of late mortality/morbidity in future decades is projected to be lower than that for survivors from earlier eras. Nevertheless, the risk of late effects such as intestinal obstruction and kidney failure was elevated across all treatment groups, and there was a dose-dependent increase in risk for all grade 3-5 CHCs by treatment group intensity.