Impact of autophagy inhibition on intervertebral disc cells and extracellular matrix.

Rebecca KritschilVivian LiDong WangQing DongPrashanta SilwalToren FinkelJoon LeeGwendolyn SowaNam Vo

Published in: JOR spine (2023)

-mediated macroautophagy in NP tissue implicates other compensatory mechanisms, highlighting additional research needed to elucidate the complex biology of autophagy in regulating age-dependent IDD.

Keyphrases

extracellular matrix
induced apoptosis

endoplasmic reticulum stress
cell death

cell cycle arrest
signaling pathway

oxidative stress
cell proliferation