Rictor, an mTORC2 Protein, Regulates Murine Lymphatic Valve Formation Through the AKT-FOXO1 Signaling.
Richa BanerjeeLuz A KnauerDrishya IyerSara E BarlowHanan ShalabyRazieh DehghanJoshua P ScallanYing YangPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Our work identifies a novel role for RICTOR in the mechanotransduction signaling pathway, wherein it activates AKT and prevents the nuclear accumulation of the valve repressor, FOXO1, which ultimately enables the formation and maintenance of lymphatic valves.
Keyphrases
- signaling pathway
- aortic valve
- pi k akt
- mitral valve
- aortic stenosis
- lymph node
- aortic valve replacement
- induced apoptosis
- transcatheter aortic valve replacement
- epithelial mesenchymal transition
- transcatheter aortic valve implantation
- cell proliferation
- transcription factor
- genome wide
- protein protein
- ejection fraction
- left ventricular
- heart failure
- binding protein
- oxidative stress
- small molecule
- gene expression
- endoplasmic reticulum stress