A genetic and proteomic comparison of key AD biomarkers across tissues.
Thomas W MarshDaniel WesternJigyasha TimsinaPriyanka GorijalaChengran YangPau PastorMenghan LiuJohn C MorrisRandall J BatemanSuzanne E SchindlerYun Ju Sungnull nullCruchaga CarlosPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
The identification of novel protein quantitative trait loci (pQTLs) in both plasma and cerebrospinal fluid (CSF). Plasma and CSF levels of neurodegeneration-related proteins correlated weakly. CSF is more informative than plasma for genetic studies of Alzheimer's disease (AD). Neurofilament light (NfL), triggering receptor expressed on myeloid cells 2 (TREM2), and chitinase-3-like protein 1 (YKL-40) tend to show relatively strong inter-tissue associations. A novel signal in the apolipoprotein E (APOE) region was identified, which is an eQTL for APOC1.
Keyphrases
- cerebrospinal fluid
- genome wide
- induced apoptosis
- cognitive decline
- dna methylation
- bone marrow
- gene expression
- copy number
- acute myeloid leukemia
- cell cycle arrest
- dendritic cells
- type diabetes
- oxidative stress
- immune response
- protein protein
- skeletal muscle
- signaling pathway
- adipose tissue
- mild cognitive impairment
- pi k akt
- clinical evaluation