The vasorelaxant effect of antidiabetic drug nateglinide via activation of voltage-dependent K+ channels in aortic smooth muscle.

Hongliang LiHye Won KimSung Eun ShinMi Seon SeoJin Ryeol AnWon-Kyo JungKwon-Soo HaEun-Taek HanSeok-Ho HongHyoweon BangIl-Whan ChoiSung Hun NaWon Sun Park

Published in: Cardiovascular therapeutics (2017)

Nateglinide induced vasorelaxation via the activation of the Kv channel independent of other K+ channels, Ca2+ channels, intracellular Ca2+ ([Ca2+ ]i ), and the endothelium.

Keyphrases

smooth muscle
protein kinase
nitric oxide
drug induced
aortic valve
high glucose
diabetic rats
pulmonary artery
reactive oxygen species
oxidative stress
endothelial cells
image quality
atrial fibrillation
dual energy
electronic health record