Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.

Florian HinzeChristoph DieterichMichael H RadkeHenk GranzierMichael Gotthardt

Published in: Journal of molecular medicine (Berlin, Germany) (2016)

Increasing the length of titin isoforms improves ventricular filling in heart disease. FHL proteins are regulated via RBM20 and adapt cardiac growth. RBM20 is a therapeutic target in diastolic dysfunction.

Keyphrases

left ventricular
heart failure
oxidative stress
blood pressure
pulmonary hypertension
transcription factor
ejection fraction