Faecal virome transplantation decreases symptoms of type 2 diabetes and obesity in a murine model.
Torben Sølbeck RasmussenCaroline Märta Junker MentzelWitold KotJosué Leonardo Castro-MejíaSimone ZuffaJonathan Richard SwannLars Hestbjerg HansenFinn Kvist VogensenAxel Kornerup HansenDennis Sandris NielsenPublished in: Gut (2020)
Transfer of caecal viral communities from mice with a lean phenotype into mice with an obese phenotype led to reduced weight gain and normalised blood glucose parameters relative to lean mice. We hypothesise that this effect is mediated via FVT-induced GM changes.
Keyphrases
- weight gain
- high fat diet induced
- blood glucose
- weight loss
- body mass index
- insulin resistance
- metabolic syndrome
- type diabetes
- adipose tissue
- birth weight
- sars cov
- wild type
- blood pressure
- bariatric surgery
- bone mineral density
- glycemic control
- skeletal muscle
- diabetic rats
- stem cells
- depressive symptoms
- physical activity
- endothelial cells
- cell therapy
- drug induced
- postmenopausal women
- obese patients