Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort.

Jiachen ChenAhmed A Y RagabMargaret F DoyleMichael L AloscoYuan FangJesse MezClaudia L SatizabalWei Qiao QiuJoanne M MurabitoKathryn L Lunetta

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Higher CDCP1, IL6, OPG, and 4E.BP1 levels were associated with smaller TCBV. Higher levels of HGF, IL8 and MMP10 were associated with smaller TCBV, CWV and FWV. Higher levels of SCF and TWEAK, were associated with larger TCBV. Significance diminished in models adjusting for CVD risk factors. Associations were observed exclusively in males.

Keyphrases

risk factors
magnetic resonance imaging
high fat diet
contrast enhanced
computed tomography
metabolic syndrome
small molecule
resting state
amino acid
skeletal muscle
functional connectivity