Type 2 diabetes is associated with loss of HDL endothelium protective functions.

Tomas VaisarErica CouzensArnold HwangMichael RussellCarolyn E BarlowLaura F DeFinaAndrew N HoofnagleFrancis Kim

Published in: PloS one (2018)

Collectively, our data suggest that HDL in individuals with type 2 diabetes loses its ability to maintain proper endothelial function independent of HDL-C, perhaps due to loss of S1P, and may contribute to development of diabetic complications.

Keyphrases

type diabetes
nitric oxide
glycemic control
cardiovascular disease
electronic health record
risk factors
insulin resistance
big data
weight loss
data analysis