Mathematical Analysis on Current-Voltage Relations via Classical Poisson-Nernst-Planck Systems with Nonzero Permanent Charges under Relaxed Electroneutrality Boundary Conditions.

We focus on a quasi-one-dimensional Poisson-Nernst-Planck model with small permanent charges for ionic flows of two oppositely charged ion species through an ion channel. Of particular interest is to examine the dynamics of ionic flows in terms of I-V (current-voltage) relations with boundary layers due to the relaxation of neutral conditions on boundary concentrations. This is achieved by employing the regular perturbation analysis on the solutions established through geometric singular perturbation analysis. Rich dynamics are observed, particularly, the nonlinear interplays among different physical parameters are characterized. Critical potentials are identified, which play critical roles in the study of ionic flows and can be estimated experimentally. Numerical simulations are performed to further illustrate and provide more intuitive understandings of our analytical results.