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Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance.

Jill V HunterAmy E CampbellJacqueline A ButterworthHelene SellierNicola L HannawaySaimir LuliAchilleas FloudasNiall S KennethAdam J MoorePhilip J BrownridgeHuw D ThomasJonathan CoxheadLeigh TaylorPeter LearyMegan S R HasoonAndrew M KnightMichelle D GarrettIan CollinsClaire E EyersNeil D Perkins
Published in: The Biochemical journal (2022)
Keyphrases
  • dna damage response
  • oxidative stress