Cancer Therapy-Related Cardiac Dysfunction: Strategies for Enhancing Cardiac Recovery.
Pavel Martinez-DominguezMaria Jose Santa Ana-BayonaEnrique C GuerraNilda Espinola-ZavaletaPublished in: Methodist DeBakey cardiovascular journal (2024)
Chemotherapy has markedly improved cancer outcomes, yet cancer therapy-related cardiac dysfunction (CTRCD) poses a significant challenge, affecting around 10% of patients. CTRCD can be asymptomatic or present with heart failure symptoms. Multimodality imaging, particularly echocardiography, remains pivotal for monitoring cardiac function. Potential biomarkers for CTRCD assessment include troponin and B-type natriuretic peptide. Pharmacological interventions, such as dexrazoxane, angiotensin-converting enzyme inhibitors, and statins, play a crucial role in primary prevention and mitigating cardiotoxicity alongside cardiac rehabilitation programs. Thus, a comprehensive approach is essential for optimal cardiac recovery and improved patient outcomes.
Keyphrases
- left ventricular
- cancer therapy
- heart failure
- end stage renal disease
- drug delivery
- oxidative stress
- cardiovascular disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- computed tomography
- physical activity
- high resolution
- type diabetes
- radiation therapy
- pulmonary hypertension
- squamous cell carcinoma
- metabolic syndrome
- atrial fibrillation
- adipose tissue
- patient reported outcomes
- photodynamic therapy
- sleep quality
- childhood cancer