Genomic characterization of colistin-resistant Klebsiella pneumoniae isolated from intensive care unit patients in Egypt.
Eriny T AttallaAmal M KhalilAzza S ZakariaDave J BakerNelly M MohamedPublished in: Annals of clinical microbiology and antimicrobials (2023)
In this study, we present the genotypic colistin resistance mechanisms in K. pneumoniae isolated in Egypt. More effective antibiotic stewardship protocols must be implemented by Egyptian health authorities to restrain this hazard and safeguard the future utility of colistin. This is the first characterization of a complete sequence of mcr-1.1-bearing IncHI2/IncHI2A plasmid recovered from K. pneumoniae clinical isolate belonging to the emerging high-risk clone ST525.
Keyphrases
- klebsiella pneumoniae
- escherichia coli
- multidrug resistant
- intensive care unit
- end stage renal disease
- acinetobacter baumannii
- gram negative
- drug resistant
- healthcare
- newly diagnosed
- chronic kidney disease
- public health
- ejection fraction
- prognostic factors
- pseudomonas aeruginosa
- gene expression
- patient reported outcomes
- respiratory tract
- amino acid
- extracorporeal membrane oxygenation
- social media