Proline selective labeling via on-site construction of naphthoxazole (NapOx).

Subhra Kanti RoyAnisha PurkaitRajib ShomeSaurav Das Debapratim Das Siddhartha Sankar Ghosh Chandan K Jana

Published in: Chemical communications (Cambridge, England) (2022)

Chemoselective construction of naphthoxazoles (NapOx) via a three-component annulation reaction enables proline selective labeling of peptides in solution or in solid-phase synthesis. The fluorogenic peptides possess low cytotoxicity, efficient cell membrane permeability and excellent bioimaging potential for biomedical applications.

Keyphrases

amino acid
quantum dots
endothelial cells
fluorescent probe
living cells
risk assessment