The CAD risk locus 9p21 increases the risk of vascular calcification in an iPSC-derived VSMC model.

Anja TrillhaaseBeatrice SchmidtMarlon MärtensUndine HaferkampJeanette ErdmannZouhair Aherrahrou

Published in: Stem cell research & therapy (2021)

Therefore, in conclusion, genetic variation or deletion of the CAD risk locus leads to an increased risk of vascular calcification. This in vitro human iPSC model of calcification could be used to develop new drug screening strategies to combat CAC.

Keyphrases

induced pluripotent stem cells
chronic kidney disease
coronary artery disease
endothelial cells
emergency department
electronic health record