Do Fetal Microchimeric Cells Influence Experimental Autoimmune Myocarditis?
Roberto Stefan de Almeida RibeiroKelly Cristina DemarqueIsrael FigueiredoIsabeliza Maria do Espírito Santo Rangel FerreiraJessica do Prado ValerianoMaurício Afonso VerícimoPublished in: Fetal and pediatric pathology (2021)
We investigated the presence and influence of fetal microchimerism in the cardiac tissue of mated female mice submitted to experimental autoimmune myocarditis. Materials and methods: Nulliparous BALB/c females and BALB/c females mated with either BALB/c males (syngeneic mating) or C57BL/6 males (allogeneic mating) were immunized with cardiac myosin peptide MyHC-α614-629 or kept as non-immunized controls. Immunization occurred 6-8 weeks after delivery and mice were assessed after 21 days. Results: Immunized mice of allogeneic mating had a lower production of anti-MyHC-α614-629 antibodies compared to immunized nulliparous mice. Immunized nulliparous females had an intense mononuclear inflammatory infiltrate in cardiac tissue, associated with fibroplasia, while mated females had a lower inflammatory reaction. An increase in the frequency of microchimeric fetal cells was observed in mice submitted to allogeneic mating following immunization. Conclusion: Allogeneic cells of fetal origin could contribute to mitigating the inflammatory response in experimental myocarditis.
Keyphrases
- stem cell transplantation
- induced apoptosis
- high fat diet induced
- bone marrow
- inflammatory response
- cell cycle arrest
- left ventricular
- oxidative stress
- hematopoietic stem cell
- insulin resistance
- type diabetes
- heart failure
- signaling pathway
- high dose
- adipose tissue
- drug induced
- mass spectrometry
- preterm birth
- binding protein
- atomic force microscopy
- high speed
- electron transfer