Sjogren's Syndrome and TAM Receptors: A Possible Contribution to Disease Onset.
Richard WitasAmmon B PeckJulian L AmbrusCuong Q NguyenPublished in: Journal of immunology research (2019)
Sjogren's syndrome (SS) is a chronic, progressive autoimmune disease featuring both organ-specific and systemic manifestations, the most frequent being dry mouth and dry eyes resulting from lymphocytic infiltration into the salivary and lacrimal glands. Like the related autoimmune disease systemic lupus erythematosus (SLE), SS patients and mouse models display accumulation of apoptotic cells and a Type I interferon (IFN) signature. Receptor tyrosine kinases (RTKs) of the Tyro3, Axl, and Mer (TAM) family are present on the surface of macrophages and dendritic cells and participate in phagocytosis of apoptotic cells (efferocytosis) and inhibition of Type I IFN signaling. This review examines the relationship between TAM receptor dysfunction and SS and explores the potential contributions of TAM defects on macrophages to SS development.
Keyphrases
- dendritic cells
- systemic lupus erythematosus
- induced apoptosis
- cell death
- cell cycle arrest
- multiple sclerosis
- immune response
- oxidative stress
- ejection fraction
- end stage renal disease
- newly diagnosed
- regulatory t cells
- mouse model
- disease activity
- case report
- anti inflammatory
- endoplasmic reticulum stress
- signaling pathway
- pi k akt
- cell proliferation
- patient reported