Cerebrospinal Fluid viral load across the spectrum of untreated HIV-1 infection: a cross-sectional multi-center study.
Gustaf UlfhammerArvid EdénAndrea AntinoriBruce J BrewAndrea CalcagnoPaola CinqueValeria De ZanLars HagbergAmy LinStaffan NilssonCristiana OpreaCarmela PinnettiSerena SpudichMattia TrunfioAlan WinstonRichard W PriceMagnus GisslénPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
Our study confirms previous smaller observations of variations in CSF HIV-RNA in different stages of HIV disease. Overall, CSF HIV-RNA was approximately 1 log10 copies/mL lower in CSF than in plasma, but CSF discordance was found in a substantial minority of subjects, most commonly in patients with HAD, indicating increasing CNS compartmentalization paralleling disease progression.