Germline DNA damage repair gene mutations in pancreatic cancer patients with personal/family histories of pancreas/breast/ovarian/prostate cancer in a Japanese population.

Tatsuo Hata Masamichi Mizuma Fuyuhiko Motoi Masaharu Ishida Hideo Ohtsuka Kei Nakagawa Takanori MorikawaToru FurukawaMichiaki Unno

Published in: Annals of gastroenterological surgery (2021)

A significant fraction of PDAC patients with personal/family histories of BRCA-related cancers harbored deleterious germline mutations in DDR-related genes. DDR-related germline gene mutations might be a favorable prognostic factor in patients with pancreatic cancer.

Keyphrases

dna repair
dna damage
prostate cancer
prognostic factors
radical prostatectomy
oxidative stress
drug induced